Updated 4:22 p.m. EST: President Obama issued the following statement on the resignation:
David Petraeus has provided extraordinary service to the United States for decades. By any measure, he was one of the outstanding General officers of his generation, helping our military adapt to new challenges, and leading our men and women in uniform through a remarkable period of service in Iraq and Afghanistan, where he helped our nation put those wars on a path to a responsible end. As Director of the Central Intelligence Agency, he has continued to serve with characteristic intellectual rigor, dedication, and patriotism. By any measure, through his lifetime of service David Petraeus has made our country safer and stronger.
Today, I accepted his resignation as Director of the Central Intelligence Agency. I am completely confident that the CIA will continue to thrive and carry out its essential mission, and I have the utmost confidence in Acting Director Michael Morell and the men and women of the CIA who work every day to keep our nation safe. Going forward, my thoughts and prayers are with Dave and Holly Petraeus, who has done so much to help military families through her own work. I wish them the very best at this difficult time.
Earlier:
Central Intelligence Agency Director David Petraeus has resigned, citing an extramarital affair, NBC News reports:
"Yesterday afternoon, I went to the White House and asked the President to be allowed, for personal reasons, to resign from my position," Petraeus said in his resignation letter. "After being married for over 37 years, I showed extremely poor judgment by engaging in an extramarital affair. Such behavior is unacceptable, both as a husband and as the leader of an organization such as ours."
Read more at NBC News.